structural biology and biophysics group


The Searle Group is based in Nottingham's new Centre for Biomolecular Sciences (CBS). This is a multidisciplinary Centre promoting research collaborations between Scientists from a number of Schools with complementary research interests in Chemical and Structural Biology.

We are engaged in developing an understanding at the atomic level of biomolecular structure, the nature of the weak interactions that stabilise biomolecular assemblies, the dynamic properties of biomolecules relevant to function and the nature and specificity of molecular recognition processes. Core experimental methodologies include a range of structural and biophysical probes: circular dichroism and fluorescence spectroscopy (both equilibrium and stopped flow techniques), microcalorimetry (both ITC and DSC) and particularly biomolecular NMR spectroscopy (600 and 800 MHz facilities in CBS). The group also has extensive experience in computational chemistry and molecular modelling approaches. We have molecular biology laboratories for cloning and protein expression. In 2007, we acquired state-of-the-art biomolecular mass spectrometry facilities (FTICR) to complement the structural biology and biophysics laboratories.

The Group engages in a wide range of other collaborative projects across the University in the Centre for Biomolecular Sciences, Schools of Biomedical Sciences, Pharmacy and Biosciences (at Sutton Bonnington campus). Current research is supported by the BBSRC and EPSRC of the UK, EU funding, and through collaboration with the Pharmaceutical Industry.


Positions available:

Studentships and Post-doctoral positions may be available at any time. Interested parties should contact Professor Searle directly.